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Researchers discovered that participants investing in this drug for any year, dropped excess weight within 4 weeks and have kept the load off throughout the 56 weeks in the study. Contrave is a combination in the drugs naltrexone and bupropion, which appears to reflect a whole new trend of weight-loss drugs which are made up of several active ingredient, that might make them far better and safer. Combo-pilling will be the newest fad or also the newest in the future under scrutiny and so it is just more publicly known recently, comb-pilling for losing weight has been around since the eighties. The biggest reason that using a combination of pills has become popular is the fact that by right now there are not any long term prescription slimming capsules that have been licensed by the FDA besides orlistat. 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Patients which has a history of cardiac event or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave needs to have their heart-rate and pulse monitored regularly. In addition, because the compound includes bupropion, Contrave comes which has a boxed warning to alert health care professionals and patients on the increased likelihood of suicidal thoughts and behaviors connected with antidepressant drugs. The warning also notes that serious neuropsychiatric events have been reported in patients taking bupropion for stop smoking. Most of the combinations that are used to enhance weight-loss involve an amphetamine as well as an antidepressant. Phentermine and Prozac really are a popular combination which were around for a long time, and although it has been around stuffed to truly combine the 2 and try to get FDA approval to market it as a weight reduction pill. 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